Diagnosis and management of primary biliary cholangitis in general practice

This module is designed to provide GPs with a concise overview of primary biliary cholangitis (PBC), focusing on key aspects relevant to primary care.

Learning objectives

This module will extend your knowledge and enable you to:

• Recognise the typical clinical features and key risk factors for PBC in general practice.
• Understand the appropriate initial investigations and diagnostic approach for suspected PBC in primary care.
• Be aware of differential diagnoses when liver blood tests indicate a cholestatic pattern.
• Appreciate the importance of early identification and timely referral to Hepatology or Gastroenterology.
• Understand the general management principles of PBC including medications.
• Appreciate the role of third sector organisations in supporting people with PBC.

Authors: Rebecca West, head of research and education at the PBC Foundation; Dr Helen Jarvis, GP with specialist clinical and academic interest in liver disease and liver lead at the Primary Care Society for Gastroenterology; Dr George Mells, clinical senior lecturer at Newcastle University and honorary consultant hepatologist at Newcastle upon Tyne Hospitals NHS Foundation Trust; Professor David Jones, consultant honorary hepatologist and professor of liver immunology at Newcastle University.

Published: 05.09.2025